InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABCB1

Summary

InnateDB Gene

IDBG-630429.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCB1

Gene Name

Uncharacterized protein

Synonyms

MDR1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005997

Encoded Proteins

IDBP-682128

ATP-binding cassette transporter subfamily B member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085563:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:33026387-33095702

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020806

ENSBTAP00000020806

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0008152	metabolic process
GO:0055085	transmembrane transport
GO:0072089	stem cell proliferation