InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLCD1

Summary

InnateDB Gene

IDBG-25338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCD1

Gene Name

phospholipase C, delta 1

Synonyms

NDNC3; PLC-III

Species

Homo sapiens

Ensembl Gene

ENSG00000187091

Encoded Proteins

IDBP-25340

phospholipase C, delta 1

IDBP-481540

phospholipase C, delta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:38007496-38029762

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000334661	ENSP00000335600
ENST00000417185
ENST00000461445
ENST00000463876	ENSP00000430344
ENST00000495395
ENST00000484829
ENST00000495367
ENST00000479619
ENST00000473834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0032794	GTPase activating protein binding
GO:0070300	phosphatidic acid binding
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0001525	angiogenesis
GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000010660

View Gene Order

ENSBTAG00000037726

Not yet available

Pathways

NETPATH

NetPath_25

FSH pathway

REACTOME

REACT_150312

Synthesis of IP3 and IP4 in the cytosol pathway

REACT_150154

Inositol phosphate metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00562

Inositol phosphate metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa04020

Calcium signaling pathway pathway

INOH

INOH website

Inositol phosphate metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001130964 NM_006225

HUGO

OMIM

CCDS

CCDS2671 CCDS46793

HPRD

09073

IMGT

EMBL

GenPept

RNA Seq Atlas