Homo sapiens Gene: TNFSF13 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-25388.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | TNFSF13 | ||||||||||||||||||||||
Gene Name | tumor necrosis factor (ligand) superfamily, member 13 | ||||||||||||||||||||||
Synonyms | APRIL; CD256; TALL-2; TALL2; TRDL-1; ZTNF2 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000161955 | ||||||||||||||||||||||
Encoded Proteins |
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 17:7558292-7561608 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p13.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
HuR stabilizes mRNA pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Gene Expression pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Intestinal immune network for IgA production pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.54673 Hs.579197 | ||||||||||||||||||||||
RefSeq | NM_001198622 NM_001198623 NM_001198624 NM_003808 NM_172087 NM_172088 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS11111 CCDS11112 CCDS42256 CCDS56019 CCDS73957 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||