InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNFSF13

Summary

InnateDB Gene

IDBG-635008.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF13

Gene Name

tumor necrosis factor ligand superfamily member 13

Synonyms

APRIL

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000130

Encoded Proteins

IDBP-686808

tumor necrosis factor ligand superfamily member 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161955:
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:27901945-27904808

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000141

ENSBTAP00000000141

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0002426	immunoglobulin production in mucosal tissue
GO:0002636	positive regulation of germinal center formation
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0016064	immunoglobulin mediated immune response
GO:0048298	positive regulation of isotype switching to IgA isotypes
GO:0050776	regulation of immune response