InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnfsf13

Summary

InnateDB Gene

IDBG-488114.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfsf13

Gene Name

tumor necrosis factor (ligand) superfamily, member 13

Synonyms

2310026N09Rik; April; Tall2; Trdl1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000089669

Encoded Proteins

IDBP-191674

tumor necrosis factor (ligand) superfamily, member 13

IDBP-264082

tumor necrosis factor (ligand) superfamily, member 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161955:
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69682846-69685784

Strand

Reverse strand

Band

Transcripts

ENSMUST00000018896	ENSMUSP00000018896
ENSMUST00000108648	ENSMUSP00000104288

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0002426	immunoglobulin production in mucosal tissue
GO:0002636	positive regulation of germinal center formation
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0016064	immunoglobulin mediated immune response
GO:0048298	positive regulation of isotype switching to IgA isotypes
GO:0050776	regulation of immune response

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000161955

View Gene Order

ENSBTAG00000000130

Not yet available

Pathways

NETPATH

REACTOME

REACT_198687

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_198691

HuR stabilizes mRNA pathway

REACT_233572

Gene Expression pathway

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25218

HuR stabilizes mRNA pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001159505 NM_023517

OMIM

CCDS

CCDS48827

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas