Version 5.4
Mus musculus Gene: Hoxd3
Summary
InnateDB Gene IDBG-256978.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxd3
Gene Name homeobox D3
Synonyms Hox-4.1; Hox-5.5
Species Mus musculus
Ensembl Gene ENSMUSG00000079277
Encoded Proteins
IDBP-181186
homeobox D3
IDBP-181188
homeobox D3
IDBP-256980
homeobox D3
IDBP-256982
homeobox D3
IDBP-622979
homeobox D3
IDBP-622983
homeobox D3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128652:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5\' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74711927-74748442
Strand Forward strand
Band C3
Transcripts
ENSMUST00000053932 ENSMUSP00000051355
ENSMUST00000047830 ENSMUSP00000044809
ENSMUST00000111983 ENSMUSP00000107614
ENSMUST00000111982 ENSMUSP00000107613
ENSMUST00000144040
ENSMUST00000144544 ENSMUSP00000134633
ENSMUST00000140666 ENSMUSP00000134616
ENSMUST00000190553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007160 cell-matrix adhesion
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0010628 positive regulation of gene expression
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128652
View Gene Order
ENSBTAG00000004835
Not yet available
Cross-References
SwissProt P09027
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.430708
RefSeq NM_010468 NM_010469
OMIM
CCDS CCDS38149 CCDS16145
HPRD
IMGT
MGI ID
MGI Symbol
EMBL AK138525 L24363 M18169 U03485 U03496 U56400 U56401 X73573
GenPept AAA37846 AAA37855 AAB60683 AAC52779 AAC52780 BAE23694 CAA51975
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca