Version 5.4
Homo sapiens Gene: HOXD3
Summary
InnateDB Gene IDBG-75766.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXD3
Gene Name homeobox D3
Synonyms Hox-4.1; HOX1D; HOX4; HOX4A
Species Homo sapiens
Ensembl Gene ENSG00000128652
Encoded Proteins
IDBP-75768
homeobox D3
IDBP-293517
homeobox D3
IDBP-387733
homeobox D3
IDBP-477585
homeobox D3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5\' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:176136612-176173102
Strand Forward strand
Band q31.1
Transcripts
ENST00000249440 ENSP00000249440
ENST00000410016 ENSP00000386498
ENST00000432796 ENSP00000392615
ENST00000459979
ENST00000468418 ENSP00000424734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007160 cell-matrix adhesion
GO:0007219 Notch signaling pathway
GO:0009952 anterior/posterior pattern specification
GO:0010628 positive regulation of gene expression
GO:0030878 thyroid gland development
GO:0045666 positive regulation of neuron differentiation
GO:0048704 embryonic skeletal system morphogenesis
GO:0051216 cartilage development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079277
View Gene Order
ENSBTAG00000004835
Not yet available
Cross-References
SwissProt
TrEMBL C9J1M3
UniProt Splice Variant
Entrez Gene 3232
UniGene Hs.591636 Hs.609109 Hs.730387 Hs.93574
RefSeq NM_006898 XM_005246509 XM_005246510 XM_005246511 XM_005246512 XM_005246513 XM_006712477
HUGO HGNC:5137
OMIM 142980
CCDS CCDS2270
HPRD 00863
IMGT
EMBL AC009336
GenPept
RNA Seq Atlas 3232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca