InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccr5

Summary

InnateDB Gene

IDBG-258112.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr5

Gene Name

chemokine (C-C motif) receptor 5

Synonyms

AM4-7; CD195; Cmkbr5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079227

Encoded Proteins

IDBP-258114

chemokine (C-C motif) receptor 5

IDBP-622425

chemokine (C-C motif) receptor 5

IDBP-622429

chemokine (C-C motif) receptor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160791:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:124121543-124147699

Strand

Forward strand

Band

Transcripts

ENSMUST00000097855
ENSMUST00000111442	ENSMUSP00000107069
ENSMUST00000169553
ENSMUST00000168179	ENSMUSP00000129848
ENSMUST00000171499	ENSMUSP00000127328
ENSMUST00000171579

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding

Biological Process

GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0070098	chemokine-mediated signaling pathway
GO:2000110	negative regulation of macrophage apoptotic process