Mus musculus Gene: Aoc2
Summary
InnateDB Gene IDBG-267046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aoc2
Gene Name amine oxidase, copper containing 2 (retina-specific)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000078651
Encoded Proteins
amine oxidase, copper containing 2 (retina-specific)
amine oxidase, copper containing 2 (retina-specific)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131480:
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101325063-101329702
Strand Forward strand
Band D
Transcripts
ENSMUST00000041095 ENSMUSP00000040255
ENSMUST00000107264 ENSMUSP00000102885
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0008131 primary amine oxidase activity
GO:0048038 quinone binding
GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052594 aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052595 aliphatic-amine oxidase activity
GO:0052596 phenethylamine:oxygen oxidoreductase (deaminating) activity
Biological Process
GO:0006584 catecholamine metabolic process
GO:0009308 amine metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
beta-Alanine metabolism pathway
Tyrosine metabolism pathway
Glycine, serine and threonine metabolism pathway
Phenylalanine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Phenylalanine metabolism pathway
Glycine, serine and threonine metabolism pathway
Tyrosine metabolism pathway
beta-Alanine metabolism pathway
INOH
Tryptophan degradation pathway
Phenylalanine degradation pathway
Arginine Proline metabolism pathway
Tyrosine metabolism pathway
Glycine Serine metabolism pathway
Histidine degradation pathway
PID NCI
Cross-References
SwissProt Q812C9
TrEMBL A2A4I9
UniProt Splice Variant
Entrez Gene 237940
UniGene Mm.302277
RefSeq NM_178932 XM_006533247
OMIM
CCDS CCDS25464
HPRD
IMGT
MGI ID MGI:2668431
MGI Symbol Aoc2
EMBL AF350445 AF350446 AL590969 BC150843 BC150848
GenPept AAI50844 AAI50849 AAK58864 AAK58865 CAM19554
RNA Seq Atlas 237940