InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AOC2

Summary

InnateDB Gene

IDBG-640483.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AOC2

Gene Name

retina-specific copper amine oxidase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030334

Encoded Proteins

IDBP-692751

Amine oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131480:
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:43508614-43513367

Strand

Forward strand

Band

Transcripts

ENSBTAT00000042833

ENSBTAP00000040444

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0008131	primary amine oxidase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0048038	quinone binding