Version 5.4
Homo sapiens Gene: ICAM4
Summary
InnateDB Gene IDBG-26863.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICAM4
Gene Name intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Synonyms CD242; LW
Species Homo sapiens
Ensembl Gene ENSG00000105371
Encoded Proteins
IDBP-26865
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IDBP-26867
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IDBP-243050
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10286967-10288522
Strand Forward strand
Band p13.2
Transcripts
ENST00000340992 ENSP00000342114
ENST00000380770 ENSP00000370147
ENST00000393717 ENSP00000377320
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050776 regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001014
View Gene Order
ENSBTAG00000010314
Not yet available
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.706750
RefSeq NM_001039132 NM_001544 NM_022377
HUGO
OMIM
CCDS CCDS12232 CCDS32904 CCDS42500
HPRD 00198
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca