InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BNIP3

Summary

InnateDB Gene

IDBG-641206.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BNIP3

Gene Name

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017804

Encoded Proteins

IDBP-693540

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26253785

[Mus musculus] Mitophagy-inducing proteins Bnip3 and Bnip3l play a regulatory role in the generation of robust natural killer cell memory.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176171:
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:51353458-51357472

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023684

ENSBTAP00000023684

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051020	GTPase binding

Biological Process

GO:0006915	apoptotic process
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0010637	negative regulation of mitochondrial fusion
GO:0035694	mitochondrial protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043068	positive regulation of programmed cell death
GO:0043243	positive regulation of protein complex disassembly
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0045837	negative regulation of membrane potential
GO:0046902	regulation of mitochondrial membrane permeability
GO:0050873	brown fat cell differentiation
GO:0051607	defense response to virus
GO:0071260	cellular response to mechanical stimulus
GO:0071279	cellular response to cobalt ion
GO:0071456	cellular response to hypoxia
GO:0072593	reactive oxygen species metabolic process
GO:0090141	positive regulation of mitochondrial fission
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097345	mitochondrial outer membrane permeabilization
GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia

Cellular Component

GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000176171

View Gene Order

ENSMUSG00000078566

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

mtor_4pathway

mTOR signaling pathway

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001076366

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas