Version 5.4
| Homo sapiens Gene: VKORC1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-27704.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | VKORC1 | ||||||||||||||||||
| Gene Name | vitamin K epoxide reductase complex, subunit 1 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000167397 | ||||||||||||||||||
| Encoded Proteins |
vitamin K epoxide reductase complex, subunit 1
vitamin K epoxide reductase complex, subunit 1
vitamin K epoxide reductase complex, subunit 1
vitamin K epoxide reductase complex, subunit 1
vitamin K epoxide reductase complex, subunit 1
vitamin K epoxide reductase complex, subunit 1
vitamin K epoxide reductase complex, subunit 1
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 16:31090842-31095980 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p11.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Bos taurus
Mus musculus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Post-translational protein modification pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Metabolism of proteins pathway
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| KEGG |
Ubiquinone and other terpenoid-quinone biosynthesis pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | I3L1P9 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 79001 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_024006 NM_206824 | ||||||||||||||||||
| HUGO | HGNC:23663 | ||||||||||||||||||
| OMIM | 608547 | ||||||||||||||||||
| CCDS | CCDS10703 CCDS10704 | ||||||||||||||||||
| HPRD | 10540 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC135050 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 79001 | ||||||||||||||||||