Version 5.4
Homo sapiens Gene: PON3
Summary
InnateDB Gene IDBG-27725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PON3
Gene Name paraoxonase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105852
Encoded Proteins
IDBP-27727
paraoxonase 3
IDBP-382254
paraoxonase 3
IDBP-382256
paraoxonase 3
IDBP-382259
paraoxonase 3
IDBP-382260
paraoxonase 3
IDBP-382261
paraoxonase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:95359944-95396368
Strand Reverse strand
Band q21.3
Transcripts
ENST00000265627 ENSP00000265627
ENST00000427422 ENSP00000413276
ENST00000451904 ENSP00000403850
ENST00000456855 ENSP00000391072
ENST00000418617 ENSP00000393174
ENST00000442770 ENSP00000390253
ENST00000492800
ENST00000460248
ENST00000482624
ENST00000475439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004063 aryldialkylphosphatase activity
GO:0004064 arylesterase activity
GO:0016844 strictosidine synthase activity
GO:0018733 3,4-dihydrocoumarin hydrolase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0047856 dihydrocoumarin hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0009605 response to external stimulus
GO:0010124 phenylacetate catabolic process
GO:0016311 dephosphorylation
GO:0019439 aromatic compound catabolic process
GO:0046226 coumarin catabolic process
GO:0046395 carboxylic acid catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029759
View Gene Order
ENSBTAG00000034645
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000940
HUGO
OMIM
CCDS CCDS5639
HPRD 04098
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca