Version 5.4
Bos taurus Gene: PON3
Summary
InnateDB Gene IDBG-629297.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PON3
Gene Name serum paraoxonase/lactonase 3 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000034645
Encoded Proteins
IDBP-680698
serum paraoxonase/lactonase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105852:
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:12441126-12478659
Strand Reverse strand
Band
Transcripts
ENSBTAT00000049076 ENSBTAP00000046014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004064 arylesterase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0019439 aromatic compound catabolic process
GO:0046395 carboxylic acid catabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105852
View Gene Order
ENSMUSG00000029759
View Gene Order
Cross-References
SwissProt
TrEMBL Q1JQD3
UniProt Splice Variant
Entrez Gene 510953
UniGene Bt.61272
RefSeq NM_001075479
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116035 DAAA02009788
GenPept AAI16036
RNA Seq Atlas 510953

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca