Version 5.4
Homo sapiens Gene: PPP2R2A
Summary
InnateDB Gene IDBG-281526.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R2A
Gene Name protein phosphatase 2, regulatory subunit B, alpha
Synonyms B55A; B55ALPHA; PR52A; PR55A
Species Homo sapiens
Ensembl Gene ENSG00000221914
Encoded Proteins
IDBP-12667
protein phosphatase 2, regulatory subunit B, alpha
IDBP-12669
protein phosphatase 2, regulatory subunit B, alpha
IDBP-480111
protein phosphatase 2, regulatory subunit B, alpha
IDBP-473755
protein phosphatase 2, regulatory subunit B, alpha
IDBP-482033
protein phosphatase 2, regulatory subunit B, alpha
IDBP-479933
protein phosphatase 2, regulatory subunit B, alpha
IDBP-480570
protein phosphatase 2, regulatory subunit B, alpha
IDBP-478403
protein phosphatase 2, regulatory subunit B, alpha
IDBP-478823
protein phosphatase 2, regulatory subunit B, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:26291491-26372680
Strand Forward strand
Band p21.2
Transcripts
ENST00000380737 ENSP00000370113
ENST00000315985 ENSP00000325074
ENST00000518254 ENSP00000428164
ENST00000520329 ENSP00000428542
ENST00000524169 ENSP00000430320
ENST00000518397 ENSP00000429279
ENST00000522535 ENSP00000428705
ENST00000522150
ENST00000523473
ENST00000521095
ENST00000523925 ENSP00000428800
ENST00000524099
ENST00000519636
ENST00000522482
ENST00000521557 ENSP00000428165
ENST00000519439
ENST00000521484
ENST00000523964
ENST00000520438
ENST00000518215
ENST00000518890
ENST00000517754
ENST00000518208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000278 mitotic cell cycle
GO:0006470 protein dephosphorylation
GO:0007084 mitotic nuclear envelope reassembly
GO:0007165 signal transduction
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043278 response to morphine
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022052
View Gene Order
ENSBTAG00000018317
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_1590
G1 Phase pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_2203
G2/M Transition pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_71
Gene Expression pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04530
Tight junction pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa03015
mRNA surveillance pathway pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604799 Hs.709531
RefSeq NM_001177591 NM_002717 XM_005273559
HUGO
OMIM
CCDS CCDS34867 CCDS55213
HPRD 09223
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca