InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CARM1

Summary

InnateDB Gene

IDBG-28472.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARM1

Gene Name

coactivator-associated arginine methyltransferase 1

Synonyms

PRMT4

Species

Homo sapiens

Ensembl Gene

ENSG00000142453

Encoded Proteins

IDBP-28474

coactivator-associated arginine methyltransferase 1

IDBP-28476

coactivator-associated arginine methyltransferase 1

IDBP-760106

IDBP-759849

IDBP-762945

IDBP-766017

IDBP-763011

IDBP-765328

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 [PubMed 11724789]).[supplied by OMIM, Mar 2008]
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10871513-10923070

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000327064	ENSP00000325690
ENST00000344150	ENSP00000340934
ENST00000588947	ENSP00000465417
ENST00000586221	ENSP00000467746
ENST00000590699	ENSP00000467420
ENST00000590039	ENSP00000464852
ENST00000589693	ENSP00000468319
ENST00000592516
ENST00000586298	ENSP00000467761
ENST00000586508

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	102 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0035642	histone methyltransferase activity (H3-R17 specific)
GO:0042054	histone methyltransferase activity
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0003420	regulation of growth plate cartilage chondrocyte proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0009405	pathogenesis
GO:0016032	viral process
GO:0016571	histone methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0032091	negative regulation of protein binding
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0034969	histone arginine methylation
GO:0034970	histone H3-R2 methylation
GO:0034971	histone H3-R17 methylation
GO:0035246	peptidyl-arginine N-methylation
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045600	positive regulation of fat cell differentiation
GO:0051591	response to cAMP
GO:0060350	endochondral bone morphogenesis