Version 5.4
Mus musculus Gene: Carm1
Summary
InnateDB Gene IDBG-140748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Carm1
Gene Name coactivator-associated arginine methyltransferase 1
Synonyms Prmt4
Species Mus musculus
Ensembl Gene ENSMUSG00000032185
Encoded Proteins
IDBP-140750
coactivator-associated arginine methyltransferase 1
IDBP-249735
coactivator-associated arginine methyltransferase 1
IDBP-249737
coactivator-associated arginine methyltransferase 1
IDBP-533983
coactivator-associated arginine methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142453:
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 [PubMed 11724789]).[supplied by OMIM, Mar 2008]
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21546894-21589487
Strand Forward strand
Band A3
Transcripts
ENSMUST00000034703 ENSMUSP00000034703
ENSMUST00000115395 ENSMUSP00000111053
ENSMUST00000115394 ENSMUSP00000111052
ENSMUST00000154049
ENSMUST00000130032 ENSMUSP00000117243
ENSMUST00000147749
ENSMUST00000139871
ENSMUST00000132011
ENSMUST00000130100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0035642 histone methyltransferase activity (H3-R17 specific)
GO:0042054 histone methyltransferase activity
GO:0042803 protein homodimerization activity
GO:0044212 transcription regulatory region DNA binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0009405 pathogenesis
GO:0016571 histone methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034969 histone arginine methylation
GO:0034970 histone H3-R2 methylation
GO:0034971 histone H3-R17 methylation
GO:0035246 peptidyl-arginine N-methylation
GO:0045600 positive regulation of fat cell differentiation
GO:0051591 response to cAMP
GO:0060350 endochondral bone morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142453
View Gene Order
ENSBTAG00000012048
Not yet available
Pathways
NETPATH
REACTOME
REACT_118837
Rora activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_200794
Mus musculus biological processes pathway
REACT_218274
Chromatin organization pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_241925
Circadian Clock pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_198352
REV-ERBA represses gene expression pathway
REACT_198351
RORA activates circadian gene expression pathway
REACT_268398
Orphan transporters pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_196516
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_244207
RMTs methylate histone arginines pathway
REACT_211261
Mitochondrial biogenesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_267716
Orphan transporters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
p53downstreampathway
Direct p53 effectors
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.178115
RefSeq NM_021531 NM_153141
OMIM
CCDS CCDS22906 CCDS52736
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca