Version 5.4
Homo sapiens Gene: LZTFL1
Summary
InnateDB Gene IDBG-29779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LZTFL1
Gene Name leucine zipper transcription factor-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163818
Encoded Proteins
IDBP-29781
leucine zipper transcription factor-like 1
IDBP-374390
leucine zipper transcription factor-like 1
IDBP-374391
leucine zipper transcription factor-like 1
IDBP-374394
leucine zipper transcription factor-like 1
IDBP-374395
leucine zipper transcription factor-like 1
IDBP-374399
leucine zipper transcription factor-like 1
IDBP-584949
leucine zipper transcription factor-like 1
IDBP-586753
leucine zipper transcription factor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:45823316-45916042
Strand Reverse strand
Band p21.31
Transcripts
ENST00000296135 ENSP00000296135
ENST00000418700 ENSP00000416427
ENST00000448111 ENSP00000400177
ENST00000411866 ENSP00000397589
ENST00000440576 ENSP00000416083
ENST00000445698 ENSP00000412240
ENST00000469874
ENST00000478551
ENST00000490463
ENST00000495864
ENST00000480156
ENST00000492333
ENST00000472635
ENST00000483279
ENST00000536047 ENSP00000439522
ENST00000539217 ENSP00000441784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0072594 establishment of protein localization to organelle
Cellular Component
GO:0005737 cytoplasm
GO:0034464 BBSome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025245
View Gene Order
ENSBTAG00000001484
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.174746 Hs.30824 Hs.600410 Hs.602697 Hs.637037 Hs.739270
RefSeq NM_001276378 NM_001276379 NM_020347 XM_006713207
HUGO
OMIM
CCDS CCDS2731 CCDS63608 CCDS63609
HPRD 07586
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca