Version 5.4
Bos taurus Gene: LZTFL1
Summary
InnateDB Gene IDBG-646263.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LZTFL1
Gene Name Leucine zipper transcription factor-like protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001484
Encoded Proteins
IDBP-699051
Leucine zipper transcription factor-like protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163818:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:54104730-54115435
Strand Forward strand
Band
Transcripts
ENSBTAT00000001942 ENSBTAP00000001942
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016192 vesicle-mediated transport
GO:0072594 establishment of protein localization to organelle
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0034464 BBSome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163818
View Gene Order
ENSMUSG00000025245
View Gene Order
Cross-References
SwissProt Q3ZBL4
TrEMBL F1MNG7
UniProt Splice Variant
Entrez Gene 512570
UniGene Bt.49509
RefSeq NM_001034425
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103231 BT030520 DAAA02054512
GenPept AAI03232 ABQ12960
RNA Seq Atlas 512570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca