InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LPIN1

Summary

InnateDB Gene

IDBG-30220.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPIN1

Gene Name

lipin 1

Synonyms

PAP1

Species

Homo sapiens

Ensembl Gene

ENSG00000134324

Encoded Proteins

IDBP-30222

lipin 1

IDBP-238197

lipin 1

IDBP-238199

lipin 1

IDBP-238201

lipin 1

IDBP-364259

lipin 1

IDBP-364290

lipin 1

IDBP-364292

lipin 1

IDBP-364296

lipin 1

IDBP-364305

lipin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:11677595-11827409

Strand

Forward strand

Band

p25.1

Transcripts

ENST00000256720	ENSP00000256720
ENST00000396099	ENSP00000379406
ENST00000396098	ENSP00000379405
ENST00000396097	ENSP00000379404
ENST00000404113
ENST00000449576	ENSP00000397908
ENST00000425416	ENSP00000401522
ENST00000441684	ENSP00000412578
ENST00000423495	ENSP00000392424
ENST00000454151	ENSP00000413714
ENST00000495907
ENST00000464517
ENST00000480315
ENST00000460096
ENST00000475286
ENST00000464953
ENST00000487346
ENST00000475922
ENST00000487576

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003674	molecular_function
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008195	phosphatidate phosphatase activity
GO:0042826	histone deacetylase binding
GO:0042975	peroxisome proliferator activated receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000266	mitochondrial fission
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0006642	triglyceride mobilization
GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0009062	fatty acid catabolic process
GO:0016311	dephosphorylation
GO:0019432	triglyceride biosynthetic process
GO:0031065	positive regulation of histone deacetylation
GO:0031100	organ regeneration
GO:0031529	ruffle organization
GO:0031532	actin cytoskeleton reorganization
GO:0032869	cellular response to insulin stimulus
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045598	regulation of fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046474	glycerophospholipid biosynthetic process
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0031965	nuclear membrane