Version 5.4
| Homo sapiens Gene: TBCA | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-30407.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TBCA | ||||||||||||||||||
| Gene Name | tubulin folding cofactor A | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000171530 | ||||||||||||||||||
| Encoded Proteins |
tubulin folding cofactor A
tubulin folding cofactor A
tubulin folding cofactor A
tubulin folding cofactor A
tubulin folding cofactor A
tubulin folding cofactor A
tubulin folding cofactor A
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. [provided by RefSeq, Jul 2008] The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 5:77691166-77868780 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q14.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Post-chaperonin tubulin folding pathway pathway
Protein folding pathway
Metabolism of proteins pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | E5RIW3 E5RJD8 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 6902 | ||||||||||||||||||
| UniGene | Hs.291212 Hs.548875 Hs.645768 Hs.663525 | ||||||||||||||||||
| RefSeq | NM_001297738 NM_001297740 NM_004607 XM_005248586 | ||||||||||||||||||
| HUGO | HGNC:11579 | ||||||||||||||||||
| OMIM | 610058 | ||||||||||||||||||
| CCDS | CCDS4040 CCDS75263 | ||||||||||||||||||
| HPRD | 18166 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC026717 AC035147 AC108482 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 6902 | ||||||||||||||||||