Version 5.4
Homo sapiens Gene: UNC5C
Summary
InnateDB Gene IDBG-30714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC5C
Gene Name unc-5 homolog C (C. elegans)
Synonyms UNC5H3
Species Homo sapiens
Ensembl Gene ENSG00000182168
Encoded Proteins
IDBP-374609
unc-5 homolog C (C. elegans)
IDBP-475003
unc-5 homolog C (C. elegans)
IDBP-474719
unc-5 homolog C (C. elegans)
IDBP-479239
unc-5 homolog C (C. elegans)
IDBP-810028
unc-5 homolog C (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:95162504-95549206
Strand Reverse strand
Band q22.3
Transcripts
ENST00000453304 ENSP00000406022
ENST00000513796 ENSP00000426924
ENST00000506749 ENSP00000426153
ENST00000504962 ENSP00000425117
ENST00000610318 ENSP00000483905
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005042 netrin receptor activity
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0007420 brain development
GO:0030334 regulation of cell migration
GO:0033564 anterior/posterior axon guidance
GO:0038007 netrin-activated signaling pathway
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059921
View Gene Order
ENSBTAG00000002084
Not yet available
Pathways
NETPATH
REACTOME
REACT_22384
Netrin mediated repulsion signals pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
netrin_pathway
Netrin-mediated signaling events
Cross-References
SwissProt
TrEMBL D6RE16
UniProt Splice Variant
Entrez Gene 8633
UniGene Hs.388565 Hs.711849
RefSeq NM_003728
HUGO HGNC:12569
OMIM 603610
CCDS CCDS3643
HPRD 04678
IMGT
EMBL AC097656 AC098584 AC105395 AC106881
GenPept
RNA Seq Atlas 8633

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca