InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SUCLA2

Summary

InnateDB Gene

IDBG-31230.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUCLA2

Gene Name

succinate-CoA ligase, ADP-forming, beta subunit

Synonyms

A-BETA; MTDPS5; SCS-betaA

Species

Homo sapiens

Ensembl Gene

ENSG00000136143

Encoded Proteins

IDBP-31232

succinate-CoA ligase, ADP-forming, beta subunit

IDBP-367817

succinate-CoA ligase, ADP-forming, beta subunit

IDBP-367819

succinate-CoA ligase, ADP-forming, beta subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:47936487-48001326

Strand

Reverse strand

Band

q14.2

Transcripts

ENST00000378654	ENSP00000367923
ENST00000434484	ENSP00000392771
ENST00000433022	ENSP00000415091
ENST00000493152
ENST00000484941
ENST00000481279
ENST00000467222
ENST00000497202
ENST00000470760

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	23 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006104	succinyl-CoA metabolic process
GO:0006105	succinate metabolic process
GO:0006781	succinyl-CoA pathway
GO:0008152	metabolic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022110

View Gene Order

ENSBTAG00000006759

Not yet available

Pathways

NETPATH

REACTOME

REACT_1785

Citric acid cycle (TCA cycle) pathway

REACT_1046

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa00020

Citrate cycle (TCA cycle) pathway

hsa00640

Propanoate metabolism pathway

INOH

INOH website

Citrate cycle pathway

PID NCI

Cross-References

SwissProt

Q9P2R7

TrEMBL

E5KS60 F5GXC8 F5H5G8 Q9Y4T0

UniProt Splice Variant

Entrez Gene

8803

UniGene

Hs.743361

RefSeq

NM_003850

HUGO

HGNC:11448

OMIM

603921

CCDS

CCDS9406

HPRD

06798

IMGT

EMBL

AB035863 AF058953 AK001458 AK001847 AK315513 AL080096 AL157369 AL158196 BC027587 CH471075 HQ205871 HQ205872 HQ205873 HQ205874 HQ205876 HQ205877 HQ205879 HQ205882 HQ205883 HQ205886 HQ205891 HQ205894 HQ205897

GenPept

AAC64396 AAH27587 ADP91739 ADP91740 ADP91741 ADP91742 ADP91744 ADP91745 ADP91747 ADP91750 ADP91751 ADP91754 ADP91759 ADP91762 ADP91765 BAA91703 BAA91939 BAA92873 BAG37894 CAB45708 CAI15149 CAI15153 EAX08777

RNA Seq Atlas

8803