InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.91195

Summary

InnateDB Gene

IDBG-629046.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.91195

Gene Name

succinyl-CoA ligase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006759

Encoded Proteins

IDBP-680440

succinyl-CoA ligase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136143:
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:17884901-17930933

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008894

ENSBTAP00000008894

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0046872	metal ion binding