Version 5.4
Homo sapiens Gene: ZFPM2
Summary
InnateDB Gene IDBG-32130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFPM2
Gene Name zinc finger protein, multitype 2
Synonyms DIH3; FOG2; hFOG-2; ZC2HC11B; ZNF89B
Species Homo sapiens
Ensembl Gene ENSG00000169946
Encoded Proteins
IDBP-295563
zinc finger protein, multitype 2
IDBP-479531
zinc finger protein, multitype 2
IDBP-485491
zinc finger protein, multitype 2
IDBP-474686
zinc finger protein, multitype 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21971825
ZFPM2 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors.
InnateDB Annotation from Orthologs
Summary
PMID 21971825
[Mus musculus] Zfpm2 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors. (Demonstrated in human)
Entrez Gene
Summary The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:104590733-105804532
Strand Forward strand
Band q22.3
Transcripts
ENST00000407775 ENSP00000384179
ENST00000520492 ENSP00000430757
ENST00000520027 ENSP00000428149
ENST00000524235
ENST00000511341
ENST00000522160
ENST00000517361 ENSP00000428720
ENST00000522296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001071 nucleic acid binding transcription factor activity
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0003148 outflow tract septum morphogenesis
GO:0003221 right ventricular cardiac muscle tissue morphogenesis
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0030324 lung development
GO:0045087 innate immune response (InnateDB)
GO:0045599 negative regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048568 embryonic organ development
GO:0048738 cardiac muscle tissue development
GO:0060412 ventricular septum morphogenesis
GO:0060548 negative regulation of cell death
GO:2000020 positive regulation of male gonad development
GO:2000195 negative regulation of female gonad development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022306
View Gene Order
ENSBTAG00000001649
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.431009
RefSeq NM_012082
HUGO
OMIM
CCDS CCDS47908
HPRD 04737
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca