InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ZFPM2

Summary

InnateDB Gene

IDBG-644956.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFPM2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001649

Encoded Proteins

IDBP-697628

zinc finger protein, multitype 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21971825

[Homo sapiens] ZFPM2 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors.

PMID 21971825

[Mus musculus] Zfpm2 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169946:
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:60994139-61520208

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002161

ENSBTAP00000002161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001071	nucleic acid binding transcription factor activity
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0003148	outflow tract septum morphogenesis
GO:0003221	right ventricular cardiac muscle tissue morphogenesis
GO:0007507	heart development
GO:0030324	lung development
GO:0045599	negative regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048568	embryonic organ development
GO:0048738	cardiac muscle tissue development
GO:0060412	ventricular septum morphogenesis
GO:0060548	negative regulation of cell death
GO:2000020	positive regulation of male gonad development
GO:2000195	negative regulation of female gonad development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000169946

View Gene Order

ENSMUSG00000022306

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

REACT_224553

Hemostasis pathway

REACT_198649

Factors involved in megakaryocyte development and platelet production pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BBZ5

UniProt Splice Variant

Entrez Gene

784747

UniGene

Bt.110363 Bt.58285

RefSeq

XM_003586902 XM_005215601 XM_005215602

HUGO

HGNC:16700

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02039271 DAAA02039272 DAAA02039273 DAAA02039274 DAAA02039275 DAAA02039276 DAAA02039277 DAAA02039278 DAAA02039279

GenPept

RNA Seq Atlas

784747