InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEC24B

Summary

InnateDB Gene

IDBG-33788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC24B

Gene Name

SEC24 family, member B (S. cerevisiae)

Synonyms

SEC24

Species

Homo sapiens

Ensembl Gene

ENSG00000138802

Encoded Proteins

IDBP-33790

SEC24 family, member B (S. cerevisiae)

IDBP-231460

SEC24 family, member B (S. cerevisiae)

IDBP-484655

SEC24 family, member B (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:109433772-109540896

Strand

Forward strand

Band

q25

Transcripts

ENST00000265175	ENSP00000265175
ENST00000399100	ENSP00000382051
ENST00000504968	ENSP00000428564

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001843	neural tube closure
GO:0002093	auditory receptor cell morphogenesis
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0003151	outflow tract morphogenesis
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0016192	vesicle-mediated transport
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0021747	cochlear nucleus development
GO:0035909	aorta morphogenesis
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0048208	COPII vesicle coating
GO:0060088	auditory receptor cell stereocilium organization
GO:0060425	lung morphogenesis
GO:0060463	lung lobe morphogenesis
GO:0060982	coronary artery morphogenesis
GO:0061024	membrane organization
GO:0061156	pulmonary artery morphogenesis
GO:0072358	cardiovascular system development
GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
GO:1901301	regulation of cargo loading into COPII-coated vesicle

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0030127	COPII vesicle coat
GO:0030134	ER to Golgi transport vesicle
GO:0048471	perinuclear region of cytoplasm