InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAMK2D

Summary

InnateDB Gene

IDBG-34988.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK2D

Gene Name

calcium/calmodulin-dependent protein kinase II delta

Synonyms

CAMKD

Species

Homo sapiens

Ensembl Gene

ENSG00000145349

Encoded Proteins

IDBP-34990

calcium/calmodulin-dependent protein kinase II delta

IDBP-34992

calcium/calmodulin-dependent protein kinase II delta

IDBP-34994

calcium/calmodulin-dependent protein kinase II delta

IDBP-241400

calcium/calmodulin-dependent protein kinase II delta

IDBP-241402

calcium/calmodulin-dependent protein kinase II delta

IDBP-484182

calcium/calmodulin-dependent protein kinase II delta

IDBP-481462

calcium/calmodulin-dependent protein kinase II delta

IDBP-476492

calcium/calmodulin-dependent protein kinase II delta

IDBP-475931

calcium/calmodulin-dependent protein kinase II delta

IDBP-482454

calcium/calmodulin-dependent protein kinase II delta

IDBP-483547

calcium/calmodulin-dependent protein kinase II delta

IDBP-479484

calcium/calmodulin-dependent protein kinase II delta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:113451032-113761927

Strand

Reverse strand

Band

q26

Transcripts

ENST00000296402	ENSP00000296402
ENST00000342666	ENSP00000339740
ENST00000379773	ENSP00000369098
ENST00000394524	ENSP00000378032
ENST00000394522	ENSP00000378030
ENST00000513132	ENSP00000424247
ENST00000511664	ENSP00000425824
ENST00000515496	ENSP00000423482
ENST00000514328	ENSP00000423677
ENST00000505990	ENSP00000424245
ENST00000508738	ENSP00000422566
ENST00000509594	ENSP00000423753
ENST00000509907
ENST00000505132

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017080	sodium channel regulator activity
GO:0031432	titin binding
GO:0044325	ion channel binding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001666	response to hypoxia
GO:0002026	regulation of the force of heart contraction
GO:0003254	regulation of membrane depolarization
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007268	synaptic transmission
GO:0008016	regulation of heart contraction
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014911	positive regulation of smooth muscle cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030007	cellular potassium ion homeostasis
GO:0035022	positive regulation of Rac protein signal transduction
GO:0046777	protein autophosphorylation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0055119	relaxation of cardiac muscle
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060341	regulation of cellular localization
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071277	cellular response to calcium ion
GO:0086003	cardiac muscle cell contraction
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901725	regulation of histone deacetylase activity
GO:1901897	regulation of relaxation of cardiac muscle
GO:1902305	regulation of sodium ion transmembrane transport
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005954	calcium- and calmodulin-dependent protein kinase complex
GO:0016020	membrane
GO:0030666	endocytic vesicle membrane
GO:0033017	sarcoplasmic reticulum membrane
GO:0034704	calcium channel complex
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm