Version 5.4
Bos taurus Gene: CAMK2D
Summary
InnateDB Gene IDBG-640024.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAMK2D
Gene Name Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014463
Encoded Proteins
IDBP-692230
Calcium/calmodulin-dependent protein kinase type II subunit delta
IDBP-692234
Calcium/calmodulin-dependent protein kinase type II subunit delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145349:
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:12965030-13272298
Strand Forward strand
Band
Transcripts
ENSBTAT00000019230 ENSBTAP00000019230
ENSBTAT00000039835 ENSBTAP00000039621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017080 sodium channel regulator activity
GO:0031432 titin binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0046777 protein autophosphorylation
GO:0060341 regulation of cellular localization
GO:1901897 regulation of relaxation of cardiac muscle
GO:1902305 regulation of sodium ion transmembrane transport
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145349
View Gene Order
ENSMUSG00000053819
View Gene Order
Pathways
NETPATH
REACTOME
REACT_205580
HSF1-dependent transactivation pathway
REACT_212364
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_226364
Post NMDA receptor activation events pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_212455
Interferon gamma signaling pathway
REACT_206069
Cellular responses to stress pathway
REACT_213138
Immune System pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_209867
CREB phosphorylation through the activation of CaMKII pathway
REACT_216035
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_202705
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_225183
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_218305
CREB phosphorylation through the activation of Ras pathway
REACT_225103
Interferon Signaling pathway
REACT_225032
Neuronal System pathway
REACT_219681
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_225257
Cellular response to heat stress pathway
REACT_214196
Trafficking of AMPA receptors pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_120956
Cellular responses to stress pathway
REACT_13685
Neuronal System pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_188957
Cellular responses to stress pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_198248
CREB phosphorylation through the activation of CaMKII pathway
REACT_230745
Immune System pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_213550
HSF1-dependent transactivation pathway
REACT_224790
Cellular response to heat stress pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_259290
Neuronal System pathway
REACT_258217
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04740
Olfactory transduction pathway
hsa04012
ErbB signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa05214
Glioma pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
mmu04740
Olfactory transduction pathway
mmu04012
ErbB signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04114
Oocyte meiosis pathway
mmu04971
Gastric acid secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.58299 Bt.97542
RefSeq NM_001046333 XM_005207644
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca