InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PNPLA8

Summary

InnateDB Gene

IDBG-36334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PNPLA8

Gene Name

patatin-like phospholipase domain containing 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000135241

Encoded Proteins

IDBP-36338

patatin-like phospholipase domain containing 8

IDBP-385201

patatin-like phospholipase domain containing 8

IDBP-385202

patatin-like phospholipase domain containing 8

IDBP-385204

patatin-like phospholipase domain containing 8

IDBP-385205

patatin-like phospholipase domain containing 8

IDBP-385207

patatin-like phospholipase domain containing 8

IDBP-385209

patatin-like phospholipase domain containing 8

IDBP-385210

patatin-like phospholipase domain containing 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:108470422-108569666

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000257694	ENSP00000257694
ENST00000426128	ENSP00000394988
ENST00000453144	ENSP00000387789
ENST00000422087	ENSP00000410804
ENST00000436062	ENSP00000406779
ENST00000453085	ENSP00000402274
ENST00000427008	ENSP00000406033
ENST00000415498	ENSP00000391872
ENST00000483879
ENST00000476592
ENST00000462466
ENST00000489738

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0005488	binding
GO:0005524	ATP binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006644	phospholipid metabolic process
GO:0008152	metabolic process
GO:0008219	cell death
GO:0019369	arachidonic acid metabolic process
GO:0034638	phosphatidylcholine catabolic process
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0043651	linoleic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0046338	phosphatidylethanolamine catabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050482	arachidonic acid secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036257

View Gene Order

ENSBTAG00000024387

Not yet available

Pathways

NETPATH

REACTOME

REACT_120829

Acyl chain remodelling of PC pathway

REACT_121369

Acyl chain remodelling of PE pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.613727 Hs.617340 Hs.733037

RefSeq

NM_001256007 NM_001256008 NM_001256009 NM_001256010 NM_001256011 NM_015723 XM_005250396

HUGO

OMIM

CCDS

CCDS34733 CCDS59075 CCDS59508

HPRD

13741

IMGT

EMBL

GenPept

RNA Seq Atlas