Version 5.4
Homo sapiens Gene: MAN2A1
Summary
InnateDB Gene IDBG-36385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAN2A1
Gene Name mannosidase, alpha, class 2A, member 1
Synonyms AMan II; GOLIM7; MANA2; MANII
Species Homo sapiens
Ensembl Gene ENSG00000112893
Encoded Proteins
IDBP-36387
mannosidase, alpha, class 2A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:109689366-109869625
Strand Forward strand
Band q21.3
Transcripts
ENST00000261483 ENSP00000261483
ENST00000502261
ENST00000508043
ENST00000513921
ENST00000505313
ENST00000503970
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559 alpha-mannosidase activity
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0008270 zinc ion binding
GO:0015923 mannosidase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246 carbohydrate binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0006491 N-glycan processing
GO:0007005 mitochondrion organization
GO:0007033 vacuole organization
GO:0007585 respiratory gaseous exchange
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048286 lung alveolus development
GO:0050769 positive regulation of neurogenesis
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024085
View Gene Order
ENSBTAG00000025029
Not yet available
Pathways
NETPATH
REACTOME
REACT_25302
Reactions specific to the complex N-glycan synthesis pathway pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q16706
TrEMBL Q49A69
UniProt Splice Variant
Entrez Gene 4124
UniGene Hs.432822 Hs.599751 Hs.644717
RefSeq NM_002372 XM_006714616
HUGO HGNC:6824
OMIM 154582
CCDS CCDS34209
HPRD
IMGT
EMBL BC043416 D63998 U31520
GenPept AAC50302 AAH43416 BAA10017
RNA Seq Atlas 4124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca