InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MAN2A1

Summary

InnateDB Gene

IDBG-646627.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN2A1

Gene Name

alpha-mannosidase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000025029

Encoded Proteins

IDBP-699454

mannosidase, alpha, class 2A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112893:
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:111396329-111604883

Strand

Forward strand

Band

Transcripts

ENSBTAT00000042616

ENSBTAP00000040252

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559	alpha-mannosidase activity
GO:0008270	zinc ion binding
GO:0015923	mannosidase activity
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246	carbohydrate binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0005975	carbohydrate metabolic process
GO:0006013	mannose metabolic process
GO:0006491	N-glycan processing
GO:0007005	mitochondrion organization
GO:0007033	vacuole organization
GO:0007585	respiratory gaseous exchange
GO:0048286	lung alveolus development
GO:0050769	positive regulation of neurogenesis
GO:0060042	retina morphogenesis in camera-type eye