Version 5.4
Homo sapiens Gene: SLC12A4
Summary
InnateDB Gene IDBG-37737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC12A4
Gene Name solute carrier family 12 (potassium/chloride transporters), member 4
Synonyms KCC1
Species Homo sapiens
Ensembl Gene ENSG00000124067
Encoded Proteins
IDBP-37741
solute carrier family 12 (potassium/chloride transporters), member 4
IDBP-379448
solute carrier family 12 (potassium/chloride transporters), member 4
IDBP-592898
solute carrier family 12 (potassium/chloride transporters), member 4
IDBP-597648
solute carrier family 12 (potassium/chloride transporters), member 4
IDBP-748897
IDBP-751193
IDBP-748115
IDBP-751354
IDBP-750119
IDBP-750387
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67943474-67969601
Strand Reverse strand
Band q22.1
Transcripts
ENST00000316341 ENSP00000318557
ENST00000422611 ENSP00000395983
ENST00000541864 ENSP00000438334
ENST00000537830 ENSP00000445962
ENST00000572037 ENSP00000461403
ENST00000576616 ENSP00000458902
ENST00000570616 ENSP00000463148
ENST00000575857 ENSP00000464660
ENST00000572476
ENST00000574665
ENST00000571299 ENSP00000464168
ENST00000573023
ENST00000572766
ENST00000573702
ENST00000576377 ENSP00000458975
ENST00000572010
ENST00000576513
ENST00000576462
ENST00000570802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006821 chloride transport
GO:0006884 cell volume homeostasis
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017765
View Gene Order
ENSBTAG00000018045
Not yet available
Pathways
NETPATH
REACTOME
REACT_19315
Cation-coupled Chloride cotransporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.10094 Hs.702218
RefSeq NM_001145961 NM_001145962 NM_001145963 NM_001145964 NM_005072
HUGO
OMIM
CCDS CCDS10855 CCDS54030 CCDS54031 CCDS54032
HPRD 04987
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca