Version 5.4
Bos taurus Gene: SLC12A4
Summary
InnateDB Gene IDBG-634043.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC12A4
Gene Name solute carrier family 12 member 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018045
Encoded Proteins
IDBP-685817
solute carrier family 12 (potassium/chloride transporters), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124067:
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:35547822-35569646
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024019 ENSBTAP00000024019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000124067
View Gene Order
ENSMUSG00000017765
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19315
Cation-coupled Chloride cotransporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_247880
Cation-coupled Chloride cotransporters pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BCI8
UniProt Splice Variant
Entrez Gene 533876
UniGene Bt.62255 Bt.76435
RefSeq NM_001174091 XM_005218657 XM_005218658 XM_005218659 XM_005218660 XM_005218661 XM_005218662 XM_005218663
HUGO HGNC:10913
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046690
GenPept
RNA Seq Atlas 533876

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca