Version 5.4
Homo sapiens Gene: DPEP2
Summary
InnateDB Gene IDBG-37912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPEP2
Gene Name dipeptidase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167261
Encoded Proteins
IDBP-242793
dipeptidase 2
IDBP-747522
IDBP-752304
IDBP-746379
IDBP-752411
IDBP-749262
IDBP-749368
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67987394-68000586
Strand Reverse strand
Band q22.1
Transcripts
ENST00000268795
ENST00000393847 ENSP00000377430
ENST00000573808 ENSP00000463604
ENST00000575203 ENSP00000459375
ENST00000575510 ENSP00000462652
ENST00000572888 ENSP00000458977
ENST00000572624 ENSP00000460169
ENST00000574316
ENST00000574865 ENSP00000461250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008238 exopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0016805 dipeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006691 leukotriene metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053687
View Gene Order
ENSBTAG00000039426
Not yet available
Pathways
NETPATH
REACTOME
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3KSU4
UniProt Splice Variant
Entrez Gene 64174
UniGene Hs.372633
RefSeq NM_022355 XM_005256085 XM_005256086 XM_005256087
HUGO HGNC:23028
OMIM 609925
CCDS CCDS10857
HPRD 07011
IMGT
EMBL AC040162
GenPept
RNA Seq Atlas 64174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca