Version 5.4
| Homo sapiens Gene: MX1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-3941.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | MX1 | ||||||||||||||||||||||
| Gene Name | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | ||||||||||||||||||||||
| Synonyms | IFI-78K; IFI78; MX; MxA | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000157601 | ||||||||||||||||||||||
| Encoded Proteins |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
MX dynamin-like GTPase 1
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
MX1 is an interferon-induced member of the dynamin superfamily of large GTPases, which inhibit a wide range of viruses by blocking an early stage of the replication cycle.
MX1 GTPase is a key mediator of cell-autonomous innate immunity against a broad range of viruses such as influenza and bunyaviruses.
MX1 expression is upregulated by alpha-defensins in gigival epithelial cell.
Antiviral specificity of MX1 against orthomyxoviruses (influenza A and Thogoto viruses) is determined by a few critical amino acids in the disordered loop L4 of MX1.
NRAV, a long noncoding RNA, modulates antiviral responses by negatively regulating the initial transcription of multiple critical interferon-stimulated genes, including IFITM3 and MX1, by affecting their histone modification.
MX1 prevents influenza A virus (IAV) replication by disassembling into dimers and binding to IAV nucleoprotein synthesized following primary transcription.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2009] This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 21:41420304-41459214 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | q22.3 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Interferon alpha/beta signaling pathway
ISG15 antiviral mechanism pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Hs.517307 Hs.679475 | ||||||||||||||||||||||
| RefSeq | NM_001144925 NM_001178046 NM_001282920 NM_002462 XM_005260978 XM_005260980 XM_005260981 XM_005260982 XM_006724005 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS13673 CCDS74796 | ||||||||||||||||||||||
| HPRD | 00919 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||