Version 5.4
| Bos taurus Gene: MX1 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-639306.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | MX1 | ||||||||||||||||
| Gene Name | Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed | ||||||||||||||||
| Synonyms | Mx1-b; Mx1B | ||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000030913 | ||||||||||||||||
| Encoded Proteins |
Interferon-induced GTP-binding protein Mx1Interferon-induced GTP-binding protein Mx1, N-terminally processed
Interferon-induced GTP-binding protein Mx1Interferon-induced GTP-binding protein Mx1, N-terminally processed
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||
| Summary |
[Homo sapiens] MX1 is an interferon-induced member of the dynamin superfamily of large GTPases, which inhibit a wide range of viruses by blocking an early stage of the replication cycle.
[Homo sapiens] MX1 GTPase is a key mediator of cell-autonomous innate immunity against a broad range of viruses such as influenza and bunyaviruses.
[Homo sapiens] MX1 expression is upregulated by alpha-defensins in gigival epithelial cell.
[Homo sapiens] Antiviral specificity of MX1 against orthomyxoviruses (influenza A and Thogoto viruses) is determined by a few critical amino acids in the disordered loop L4 of MX1.
[Homo sapiens] NRAV, a long noncoding RNA, modulates antiviral responses by negatively regulating the initial transcription of multiple critical interferon-stimulated genes, including IFITM3 and MX1, by affecting their histone modification.
[Homo sapiens] MX1 prevents influenza A virus (IAV) replication by disassembling into dimers and binding to IAV nucleoprotein synthesized following primary transcription.
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| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157601:
In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2009] This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 1:143176083-143204865 | ||||||||||||||||
| Strand | Forward strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
Interferon alpha/beta signaling pathway
ISG15 antiviral mechanism pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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| KEGG | |||||||||||||||||
| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Cross-References | |||||||||||||||||
| SwissProt | P79135 | ||||||||||||||||
| TrEMBL | I3QQD7 Q867D4 | ||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 280872 | ||||||||||||||||
| UniGene | Bt.4675 | ||||||||||||||||
| RefSeq | NM_173940 XM_005201988 XM_005201989 XM_005201990 XM_005201991 | ||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | AB060169 AB060170 AF047692 AY251194 AY251195 AY251196 AY251197 AY251198 AY251199 AY251200 AY251201 AY251202 BC118109 JQ766265 U88329 | ||||||||||||||||
| GenPept | AAC13166 AAC18655 AAI18110 AAO74571 AFK14102 BAC56980 BAC56981 | ||||||||||||||||
| RNA Seq Atlas | 280872 | ||||||||||||||||