Version 5.4
| Mus musculus Gene: Ctsf | |||||
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| Summary | |||||
| InnateDB Gene | IDBG-394161.4 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | Ctsf | ||||
| Gene Name | cathepsin F | ||||
| Synonyms | AI481912 | ||||
| Species | Mus musculus | ||||
| Ensembl Gene | ENSMUSG00000083282 | ||||
| Encoded Proteins |
cathepsin F
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||
| Entrez Gene | |||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174080:
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||
| Type | Protein coding | ||||
| Genomic Location | Chromosome 19:4855129-4860912 | ||||
| Strand | Forward strand | ||||
| Band | A | ||||
| Transcripts |
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| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||
| NETPATH | |||||
| REACTOME |
Immune System pathway
MHC class II antigen presentation pathway
Adaptive Immune System pathway
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| KEGG |
Lysosome pathway
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| INOH | |||||
| PID NCI | |||||
| Pathway Predictions based on Human Orthology Data | |||||
| NETPATH | |||||
| REACTOME |
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
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| KEGG |
Lysosome pathway
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| INOH | |||||
| PID NCI | |||||
| Cross-References | |||||
| SwissProt | Q9R013 | ||||
| TrEMBL | Q99KQ9 | ||||
| UniProt Splice Variant | |||||
| Entrez Gene | 56464 | ||||
| UniGene | |||||
| RefSeq | NM_019861 | ||||
| OMIM | |||||
| CCDS | CCDS29440 | ||||
| HPRD | |||||
| IMGT | |||||
| MGI ID | MGI:1861434 | ||||
| MGI Symbol | Ctsf | ||||
| EMBL | AF136280 AF217224 AJ131851 AK075862 BC004054 BC058758 | ||||
| GenPept | AAF13147 AAF37228 AAH04054 AAH58758 BAC36013 CAB42884 | ||||
| RNA Seq Atlas | 56464 | ||||