Bos taurus Gene: CTSF | |||||
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Summary | |||||
InnateDB Gene | IDBG-644457.3 | ||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
Gene Symbol | CTSF | ||||
Gene Name | cathepsin F precursor | ||||
Synonyms | |||||
Species | Bos taurus | ||||
Ensembl Gene | ENSBTAG00000010994 | ||||
Encoded Proteins |
cathepsin F
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Protein Structure | |||||
Useful resources | Stemformatics EHFPI ImmGen | ||||
Entrez Gene | |||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174080:
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||
Type | Protein coding | ||||
Genomic Location | Chromosome 29:45242552-45248115 | ||||
Strand | Reverse strand | ||||
Band | |||||
Transcripts |
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Interactions | |||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||
NETPATH | |||||
REACTOME |
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
Immune System pathway
MHC class II antigen presentation pathway
Adaptive Immune System pathway
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KEGG |
Lysosome pathway
Lysosome pathway
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INOH | |||||
PID NCI | |||||
Cross-References | |||||
SwissProt | |||||
TrEMBL | Q0VCU3 | ||||
UniProt Splice Variant | |||||
Entrez Gene | 509715 | ||||
UniGene | Bt.7264 | ||||
RefSeq | NM_001075416 XM_005227037 | ||||
HUGO | |||||
OMIM | |||||
CCDS | |||||
HPRD | |||||
IMGT | |||||
EMBL | BC120003 DAAA02063594 | ||||
GenPept | AAI20004 | ||||
RNA Seq Atlas | 509715 | ||||