Version 5.4
Homo sapiens Gene: MYL6B
Summary
InnateDB Gene IDBG-40062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL6B
Gene Name myosin, light chain 6B, alkali, smooth muscle and non-muscle
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196465
Encoded Proteins
IDBP-594059
myosin, light chain 6B, alkali, smooth muscle and non-muscle
IDBP-592037
myosin, light chain 6B, alkali, smooth muscle and non-muscle
IDBP-588299
myosin, light chain 6B, alkali, smooth muscle and non-muscle
IDBP-600584
myosin, light chain 6B, alkali, smooth muscle and non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56152256-56159647
Strand Forward strand
Band q13.2
Transcripts
ENST00000405661
ENST00000553066 ENSP00000450385
ENST00000550443 ENSP00000446643
ENST00000551834 ENSP00000448198
ENST00000552568 ENSP00000446965
ENST00000550152
ENST00000549178
ENST00000548548
ENST00000550550
ENST00000549380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006936 muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0030049 muscle filament sliding
Cellular Component
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0016459 myosin complex
GO:0016461 unconventional myosin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039824
View Gene Order
ENSBTAG00000031217
Not yet available
Pathways
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8VSA2 F8W1I5
UniProt Splice Variant
Entrez Gene 140465
UniGene
RefSeq NM_001199629 NM_002475
HUGO HGNC:29823
OMIM 609930
CCDS CCDS8905
HPRD 14721
IMGT
EMBL AC034102
GenPept
RNA Seq Atlas 140465

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca