Version 5.4
Homo sapiens Gene: TNFRSF13B
Summary
InnateDB Gene IDBG-408940.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF13B
Gene Name tumor necrosis factor receptor superfamily, member 13B
Synonyms CD267; CVID; CVID2; RYZN; TACI; TNFRSF14B
Species Homo sapiens
Ensembl Gene ENSG00000240505
Encoded Proteins
IDBP-32575
tumor necrosis factor receptor superfamily, member 13B
IDBP-758578
IDBP-762761
IDBP-761714
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:16929816-16972118
Strand Reverse strand
Band p11.2
Transcripts
ENST00000261652 ENSP00000261652
ENST00000584950 ENSP00000463582
ENST00000583789 ENSP00000462952
ENST00000581616
ENST00000579009
ENST00000579315 ENSP00000464069
ENST00000582931
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007166 cell surface receptor signaling pathway
GO:0030889 negative regulation of B cell proliferation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010142
View Gene Order
ENSBTAG00000015298
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05340
Primary immunodeficiency pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.158341
RefSeq NM_012452
HUGO
OMIM
CCDS CCDS11181
HPRD 05365
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca