Version 5.4
Mus musculus Gene: Tnfrsf13b
Summary
InnateDB Gene IDBG-182161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf13b
Gene Name tumor necrosis factor receptor superfamily, member 13b
Synonyms 1200009E08Rik; Taci
Species Mus musculus
Ensembl Gene ENSMUSG00000010142
Encoded Proteins
IDBP-182163
tumor necrosis factor receptor superfamily, member 13b
IDBP-182167
tumor necrosis factor receptor superfamily, member 13b
IDBP-542726
tumor necrosis factor receptor superfamily, member 13b
IDBP-532193
tumor necrosis factor receptor superfamily, member 13b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000240505:
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61126755-61149372
Strand Forward strand
Band B2
Transcripts
ENSMUST00000010286 ENSMUSP00000010286
ENSMUST00000101103 ENSMUSP00000098662
ENSMUST00000146033 ENSMUSP00000116943
ENSMUST00000139422 ENSMUSP00000116175
ENSMUST00000137832
ENSMUST00000130708
ENSMUST00000123378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0030889 negative regulation of B cell proliferation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000240505
View Gene Order
ENSBTAG00000015298
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu05340
Primary immunodeficiency pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05340
Primary immunodeficiency pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.265915
RefSeq NM_021349 XM_006533851 XM_006533852
OMIM
CCDS CCDS24806
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca