Version 5.4
Homo sapiens Gene: GLS2
Summary
InnateDB Gene IDBG-41154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLS2
Gene Name glutaminase 2 (liver, mitochondrial)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135423
Encoded Proteins
IDBP-41156
glutaminase 2 (liver, mitochondrial)
IDBP-378054
glutaminase 2 (liver, mitochondrial)
IDBP-477667
glutaminase 2 (liver, mitochondrial)
IDBP-475511
glutaminase 2 (liver, mitochondrial)
IDBP-484810
glutaminase 2 (liver, mitochondrial)
IDBP-479707
glutaminase 2 (liver, mitochondrial)
IDBP-475119
glutaminase 2 (liver, mitochondrial)
IDBP-475401
glutaminase 2 (liver, mitochondrial)
IDBP-598229
glutaminase 2 (liver, mitochondrial)
IDBP-806651
glutaminase 2 (liver, mitochondrial)
IDBP-806652
glutaminase 2 (liver, mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56470944-56488414
Strand Reverse strand
Band q13.3
Transcripts
ENST00000311966 ENSP00000310447
ENST00000390288
ENST00000424141 ENSP00000416282
ENST00000479952 ENSP00000417796
ENST00000486433 ENSP00000420328
ENST00000476991
ENST00000496006
ENST00000486896 ENSP00000419661
ENST00000494474 ENSP00000419996
ENST00000461077 ENSP00000417244
ENST00000494345
ENST00000483347 ENSP00000417723
ENST00000471282
ENST00000491880
ENST00000539272 ENSP00000441739
ENST00000623608 ENSP00000485315
ENST00000610413 ENSP00000483010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004359 glutaminase activity
GO:0005515 protein binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006541 glutamine metabolic process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0008652 cellular amino acid biosynthetic process
GO:0014047 glutamate secretion
GO:0034641 cellular nitrogen compound metabolic process
GO:0042981 regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044005
View Gene Order
ENSBTAG00000009284
Not yet available
Pathways
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00471
D-Glutamine and D-glutamate metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt Q9UI32
TrEMBL A8K0A6 B7Z8Q9 C9J3Q2 E5G745 F8WBC9 F8WBL8 F8WEU7 G5E9X4 Q0VD99
UniProt Splice Variant
Entrez Gene 27165
UniGene Hs.212606
RefSeq NM_001280796 NM_001280797 NM_001280798 NM_013267 XM_005268797
HUGO HGNC:29570
OMIM 606365
CCDS CCDS73482 CCDS8921
HPRD
IMGT
EMBL AC097104 AF110330 AF110331 AF223944 AF348119 AK289471 AK303772 BC119767 BC119768 CH471054 HM775424
GenPept AAF21933 AAF21934 AAF33826 AAI19768 AAI19769 AAO13298 ADR77823 BAF82160 BAH14045 EAW96942 EAW96943
RNA Seq Atlas 27165

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca