Version 5.4
Bos taurus Gene: GLS2
Summary
InnateDB Gene IDBG-635909.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLS2
Gene Name glutaminase liver isoform, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009284
Encoded Proteins
IDBP-687784
glutaminase 2 (liver, mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135423:
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:57241073-57253590
Strand Forward strand
Band
Transcripts
ENSBTAT00000012233 ENSBTAP00000012233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004359 glutaminase activity
GO:0005515 protein binding
Biological Process
GO:0006541 glutamine metabolic process
GO:0042981 regulation of apoptotic process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135423
View Gene Order
ENSMUSG00000044005
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_250087
Neurotransmitter Release Cycle pathway
REACT_259290
Neuronal System pathway
REACT_239550
Amino acid synthesis and interconversion (transamination) pathway
REACT_229514
Glutamate Neurotransmitter Release Cycle pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00471
D-Glutamine and D-glutamate metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
mmu00471
D-Glutamine and D-glutamate metabolism pathway
mmu00330
Arginine and proline metabolism pathway
mmu00250
Alanine, aspartate and glutamate metabolism pathway
mmu04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E1BHZ6
UniProt Splice Variant
Entrez Gene 539561
UniGene Bt.105076 Bt.20157
RefSeq NM_001192274 XM_005206655 XM_005206656 XM_005206658
HUGO HGNC:29570
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013527
GenPept
RNA Seq Atlas 539561

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca