InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STAT6

Summary

InnateDB Gene

IDBG-42122.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT6

Gene Name

signal transducer and activator of transcription 6, interleukin-4 induced

Synonyms

D12S1644; IL-4-STAT; STAT6B; STAT6C

Species

Homo sapiens

Ensembl Gene

ENSG00000166888

Encoded Proteins

IDBP-42124

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-378397

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-597981

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-599741

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-592916

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-599561

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-594403

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-598811

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-602214

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-601170

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-599809

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-591394

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-584747

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-602061

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-600201

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-589041

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-588582

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-590509

signal transducer and activator of transcription 6, interleukin-4 induced

IDBP-593211

signal transducer and activator of transcription 6, interleukin-4 induced

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17971840

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that mediates IL-13 cytokine signaling.

PMID 16433852

STAT6 plays a role in the interleukin-4 (IL-4)-mediated modulation of TLR4 expression and the responsiveness of cells to lipopolysaccharide (LPS).

PMID 22000020

STAT6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22000020

[Mus musculus] Stat6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing.

PMID 26953325

[Mus musculus] Stat6 signalling negatively regulates γδ17 T cells, which plays a front-line role in mucosal immunity.

Entrez Gene

Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:57095408-57132139

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000300134	ENSP00000300134
ENST00000454075	ENSP00000401486
ENST00000555222
ENST00000538913	ENSP00000445409
ENST00000557563
ENST00000543873	ENSP00000438451
ENST00000556155	ENSP00000451742
ENST00000537215	ENSP00000444530
ENST00000554764	ENSP00000451909
ENST00000555318	ENSP00000450428
ENST00000554202
ENST00000555375	ENSP00000450921
ENST00000553533	ENSP00000451546
ENST00000557781
ENST00000555641
ENST00000555849	ENSP00000452394
ENST00000556259	ENSP00000452373
ENST00000553499	ENSP00000451074
ENST00000553397	ENSP00000452203
ENST00000555104	ENSP00000450510
ENST00000554663	ENSP00000450665
ENST00000554825	ENSP00000451209
ENST00000557635	ENSP00000450747
ENST00000553275	ENSP00000450732

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	79 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002296	T-helper 1 cell lineage commitment
GO:0002829	negative regulation of type 2 immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0032481	positive regulation of type I interferon production
GO:0033598	mammary gland epithelial cell proliferation
GO:0034097	response to cytokine
GO:0035771	interleukin-4-mediated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0060443	mammary gland morphogenesis
GO:0070301	cellular response to hydrogen peroxide
GO:1902170	cellular response to reactive nitrogen species