Bos taurus Gene: STAT6 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-635695.3 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | STAT6 | ||||||||||||||||||||||||
Gene Name | signal transducer and activator of transcription 6 | ||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000006335 | ||||||||||||||||||||||||
Encoded Proteins |
signal transducer and activator of transcription 6, interleukin-4 induced
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Homo sapiens] Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that mediates IL-13 cytokine signaling.
[Homo sapiens] STAT6 plays a role in the interleukin-4 (IL-4)-mediated modulation of TLR4 expression and the responsiveness of cells to lipopolysaccharide (LPS).
[Homo sapiens] STAT6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing. (Demonstrated in mice)
[Mus musculus] Stat6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing.
[Mus musculus] Stat6 signalling negatively regulates γδ17 T cells, which plays a front-line role in mucosal immunity.
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166888:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 5:56658077-56670842 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | |||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
IL4 pathway
IL9 pathway
TSLP pathway
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REACTOME |
STING mediated induction of host immune responses pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Innate Immune System pathway
Signal Transduction pathway
Immune System pathway
Cytosolic sensors of pathogen-associated DNA pathway
STAT6-mediated induction of chemokines pathway
Innate Immune System pathway
STAT6-mediated induction of chemokines pathway
Immune System pathway
Downstream signal transduction pathway
Cytosolic sensors of pathogen-associated DNA pathway
STING mediated induction of host immune responses pathway
Signaling by PDGF pathway
Signal Transduction pathway
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KEGG |
Jak-STAT signaling pathway pathway
Jak-STAT signaling pathway pathway
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INOH |
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
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PID NCI |
IL12-mediated signaling events
Signaling events mediated by TCPTP
IL4-mediated signaling events
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Bt.106674 | ||||||||||||||||||||||||
RefSeq | NM_001205501 XM_005206514 XM_005206515 | ||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||