InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL5

Summary

InnateDB Gene

IDBG-42236.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL5

Gene Name

interleukin 5 (colony-stimulating factor, eosinophil)

Synonyms

EDF; IL-5; TRF

Species

Homo sapiens

Ensembl Gene

ENSG00000113525

Encoded Proteins

IDBP-42238

interleukin 5 (colony-stimulating factor, eosinophil)

IDBP-376310

interleukin 5 (colony-stimulating factor, eosinophil)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24631157

[Mus musculus] Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008]
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:132541444-132556838

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000231454	ENSP00000231454
ENST00000450655	ENSP00000409825
ENST00000462418

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	10 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005137	interleukin-5 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0030890	positive regulation of B cell proliferation
GO:0045645	positive regulation of eosinophil differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046427	positive regulation of JAK-STAT cascade
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051024	positive regulation of immunoglobulin secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0071803	positive regulation of podosome assembly