Version 5.4
Bos taurus Gene: IL5
Summary
InnateDB Gene IDBG-644678.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL5
Gene Name Interleukin-5
Synonyms IL-5; TRF
Species Bos taurus
Ensembl Gene ENSBTAG00000031235
Encoded Proteins
IDBP-697330
Interleukin-5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24631157
[Mus musculus] Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113525:
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008]
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:23184382-23186782
Strand Forward strand
Band
Transcripts
ENSBTAT00000044228 ENSBTAP00000041739
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005137 interleukin-5 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0006955 immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0071803 positive regulation of podosome assembly
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113525
View Gene Order
ENSMUSG00000036117
View Gene Order
Pathways
NETPATH
REACTOME
REACT_205369
Signaling by GPCR pathway
REACT_226349
Interleukin-2 signaling pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_223657
Interleukin receptor SHC signaling pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_214353
Signal Transduction pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_214436
GPCR downstream signaling pathway
REACT_203136
G-protein beta:gamma signalling pathway
REACT_211267
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_206833
Signaling by Interleukins pathway
REACT_202218
G beta:gamma signalling through PI3Kgamma pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_17
IL5 pathway
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_261687
Signaling by Interleukins pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_188257
Signal Transduction pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05310
Asthma pathway
hsa04672
Intestinal immune network for IgA production pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu05310
Asthma pathway
mmu05330
Allograft rejection pathway
mmu05320
Autoimmune thyroid disease pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-5 signaling pathway
INOH website
GPCR signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-5 signaling pathway
INOH website
GPCR signaling pathway
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
il4_2pathway
IL4-mediated signaling events
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
il5_pathway
IL5-mediated signaling events
Cross-References
SwissProt P52173
TrEMBL B5LVM9
UniProt Splice Variant
Entrez Gene 280825
UniGene Bt.5
RefSeq NM_173922 XM_002706164
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL EU276070 EU914955 EU914956 EU914957 EU914958 EU914959 EU914960 EU914967 EU914968 EU914969 EU914970 EU914971 EU914972 EU914973 EU914974 EU914979 EU914980 EU914981 EU914982 EU914983 EU914984 EU914985 EU914986 EU914991 EU914992 EU914993 EU914994 EU914995 EU914996 EU914997 EU914998 EU914999 EU915000 EU915003 EU915004 EU915005 EU915006 EU915007 EU915008 EU915009 EU915010 EU915015 EU915016 EU915017 EU915018 EU915019 EU915020 EU915021 EU915022 EU915025 EU915026 EU915027 EU915028 EU915029 EU915030 EU915031 EU915032 EU915037 EU915038 EU915039 EU915040 EU915041 EU915042 EU915043 EU915044 Z67872
GenPept ABX72068 ACH53199 ACH53200 ACH53201 ACH53202 ACH53203 ACH53204 ACH53211 ACH53212 ACH53213 ACH53214 ACH53215 ACH53216 ACH53217 ACH53218 ACH53223 ACH53224 ACH53225 ACH53226 ACH53227 ACH53228 ACH53229 ACH53230 ACH53233 ACH53234 ACH53235 ACH53236 ACH53237 ACH53238 ACH53239 ACH53240 ACH53241 ACH53242 ACH53245 ACH53246 ACH53247 ACH53248 ACH53249 ACH53250 ACH53251 ACH53252 ACH53257 ACH53258 ACH53259 ACH53260 ACH53261 ACH53262 ACH53263 ACH53264 ACH53267 ACH53268 ACH53269 ACH53270 ACH53271 ACH53272 ACH53273 ACH53274 ACH53279 ACH53280 ACH53281 ACH53282 ACH53283 ACH53284 ACH53285 ACH53286 CAA91779
RNA Seq Atlas 100335844 280825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca