InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RXFP1

Summary

InnateDB Gene

IDBG-42822.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RXFP1

Gene Name

relaxin/insulin-like family peptide receptor 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000171509

Encoded Proteins

IDBP-42824

relaxin/insulin-like family peptide receptor 1

IDBP-586588

relaxin/insulin-like family peptide receptor 1

IDBP-42828

relaxin/insulin-like family peptide receptor 1

IDBP-379377

relaxin/insulin-like family peptide receptor 1

IDBP-379379

relaxin/insulin-like family peptide receptor 1

IDBP-480622

relaxin/insulin-like family peptide receptor 1

IDBP-599492

relaxin/insulin-like family peptide receptor 1

IDBP-476600

relaxin/insulin-like family peptide receptor 1

IDBP-809878

relaxin/insulin-like family peptide receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:158315311-158653372

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000307765	ENSP00000303248
ENST00000342048	ENSP00000432036
ENST00000343542	ENSP00000345889
ENST00000448688	ENSP00000414885
ENST00000423548	ENSP00000405841
ENST00000460056	ENSP00000423306
ENST00000472969
ENST00000471616	ENSP00000434475
ENST00000470033	ENSP00000420712
ENST00000484785
ENST00000613319	ENSP00000480522

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0042562	hormone binding
GO:0046872	metal ion binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007567	parturition
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0060427	lung connective tissue development
GO:0060658	nipple morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034009

View Gene Order

ENSBTAG00000010306

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_21314

Relaxin receptors pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.196119 Hs.591686

RefSeq

NM_001253727 NM_001253728 NM_001253729 NM_001253730 NM_001253732 NM_001253733 NM_021634

HUGO

OMIM

CCDS

CCDS43276 CCDS58929 CCDS58930 CCDS75204 CCDS75205 CCDS75206

HPRD

05975

IMGT

EMBL

GenPept

RNA Seq Atlas